ULTRASTRUCTURAL-LOCALIZATION OF MAGNESIUM-DEPENDENT ADENOSINE-TRIPHOSPHATASE IN DOG HEPATIC PEROXISOMES TREATED WITH A PEROXISOME PROLIFERATOR, ACETYLSALICYLIC-ACID

被引：0

作者：

HAKOI, K ^{[1
]}

MAKITA, T ^{[1
]}

机构：

[1] YAMAGUCHI UNIV,DEPT VET ANAT,YOSHIDA,YAMAGUCHI 753,JAPAN

来源：

BIOMEDICAL RESEARCH-TOKYO | 1994年 / 15卷 / 03期

关键词：

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

A total of 9 beagle dogs (7-10 kg, body weight) was administrated with acetylsalicylic acid (aspirin) at doses of 500 and 1,000 mg/kg/day for 7 days. Hepatomegaly was not observed in aspirin-treated dogs, but both the number and the size of peroxisomes per unit cytoplasmic area (number/mu m(2) and nm(2)/mu m(2)) were significantly increased in aspirin-treated group at day 7. Magnesium-dependent adenosine triphosphatase (Mg-ATPase) was located on the limiting membrane of aspirin-treated liver peroxisomes, but it was much less than that of intact or ordinary peroxisomes in the control dogs.

引用

页码：183 / 190

页数：8