BIOSYNTHESIS OF BIOTIN VITAMERS BY YARROWIA-LIPOLYTICA

被引：0
|
作者：
PEARSON, BM
FULLER, LJ
MCKEE, RA
机构：
[1] AFRC Institute of Food Research, Norwich Laboratory, Norwich, N R4 7U A, Colney Lane
来源：
LETTERS IN APPLIED MICROBIOLOGY | 1990年 / 10卷 / 02期
关键词：
D O I：
10.1111/j.1472-765X.1990.tb00272.x
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The hydrocarbon utilizing yeast Yarrowia lipolyyica NCYC 1421 produces biotin and its vitamers when grown on glucose in biotin‐free media. Levels of production can be influenced by the medium composition. Growth in the presence of longchained fatty acids greatly increases biotin vitamer production. The biotin vitamers produced are normally dethiobiotin and 7‐keto, 8‐aminopelargonic acid. The addition of succinic acid at 0.5 g per litre causes the vitamer 7, 8‐diaminopelargonic acid to be produced at high levels. The biotin antagonist α‐dehydrobiotin inhibits the growth of Yarrowia lipolytica. Mutants can be readily isolated which show resistance to α‐dehydrobiotin, but these do not produce greater amounts of biotin or its vitamers. Copyright © 1990, Wiley Blackwell. All rights reserved
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页码：89 / 91
页数：3
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