SELF EMULSIFYING DRUG DELIVERY SYSTEM: A REVIEW

The oral route is easiest and most convenient route for drug administration. The major problem in oral drug formulations is low and erratic bioavailability, which mainly results from poor water solubility. This may leads to higher inter subject and intra subject variability and therapeutic failure. The improvement of compounds solubility and bioavailability are the greatest challenges in formulations. The self emulsifying drug delivery system (SEDDS) is a novel approach for enhancing the solubility of formulations; by this approach it is also possible to prolong the release of drug via incorporation of polymers in SEDDS composition which appears to be unique and industrially feasible approach. The SEDDS is an isotropic mixture of oils, surfactants, co-surfactants, co-solvents, etc. It can be used for designing the formulations such as tablets, capsules, pellets, etc. The SEDDS will continue to enable novel applications in drug delivery and solve problems associated with the delivery of poorly soluble drugs.