BIOSYNTHESIS OF CORTICOTROPIN-RELEASING HORMONE IN HUMAN T-LYMPHOCYTES

被引：94
|
作者：
EKMAN, R
SERVENIUS, B
CASTRO, MG
LOWRY, PJ
CEDERLUND, AS
BERGMAN, O
SJOGREN, HO
机构：
[1] UNIV LUND,DEPT PSYCHIAT & NEUROCHEM,S-22101 LUND,SWEDEN
[2] UNIV LUND,DEPT MED MOLEC BIOL,S-22101 LUND,SWEDEN
[3] UNIV LUND,DEPT TUMOR IMMUNOL,S-22101 LUND,SWEDEN
[4] DUNDEE INST TECHNOL,DEPT MOLEC & LIFE SCI,DUNDEE,SCOTLAND
[5] UNIV READING,DEPT BIOCHEM & PHYSIOL,READING RG6 2AH,BERKS,ENGLAND
来源：
JOURNAL OF NEUROIMMUNOLOGY | 1993年 / 44卷 / 01期
关键词：
CORTICOTROPIN-RELEASING HORMONE; BIOSYNTHESIS; T-LYMPHOCYTES;
D O I：
10.1016/0165-5728(93)90262-W
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Corticotropin-releasing hormone (CRH) is a 41-amino acid neuropeptide which increases the transcription of the proopiomelanocortin (POMC) gene, as well as the biosynthesis and secretion of POMC-derived peptides. Using a specific human CRH radioimmunoassay we have shown that human T-lymphocytes contain immunoreactive CRH. We studied the effects of phytohemagglutinin (PHA) and 12-O-tetradecanoylphorbol-13-acetate (TPA) on the biosynthesis of CRH in human T-lymphocyte cell cultures. A significant increase in CRH mRNA levels was observed in human lymphocytes after 12 h of PHA/TPA treatment, while the levels decreased after 22 h. These findings could imply an immunomodulatory role for CRH that could be due to autocrine and/or paracrine interactions.
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收藏
页码：7 / 14
页数：8
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