REDUCTION OF GABA(A) AND GABA(B) RECEPTOR DENSITIES IN THE CEREBELLAR CORTEX FROM 3-ACETYLPYRIDINE-INDUCED ATAXIC RATS

被引：4

作者：

KANNARI, K ^{[1
]}

TOMIYAMA, M ^{[1
]}

MATSUNAGA, M ^{[1
]}

机构：

[1] HIROSAKI UNIV,SCH MED,INST NEUROL DIS,DEPT NEUROL,HIROSAKI 036,AOMORI,JAPAN

来源：

BRAIN RESEARCH | 1994年 / 656卷 / 02期

关键词：

3-ACETYLPYRIDINE; INFERIOR OLIVE; ATAXIA; CEREBELLAR CORTEX; GABA(A) RECEPTOR; GABA(B) RECEPTOR; AUTORADIOGRAPHY;

D O I：

10.1016/0006-8993(94)91487-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We measured GABA(A) and GABA(B) receptor densities in the cerebellar cortex from 3-acetylpyridine-induced ataxic rats using receptor autoradiography. GABA(A) and GABA(B) receptor densities were significantly reduced both in the molecular layer and the granule cell layer. Reduction of GABA receptor densities may be induced by loss of GABA receptors on the degenerated climbing fibers or by secondary or compensatory changes of neuronal activities in the cerebellum.

引用

页码：413 / 416

页数：4

共 50 条

[1] Compartmentation of gaba b receptor2 expression in the mouse cerebellar cortex
Seung-Hyuk Chung
Chul-Tae Kim
Richard Hawkes
[J]. The Cerebellum, 2008, 7
[2] Compartmentation of gaba b receptor2 expression in the mouse cerebellar cortex
Chung, Seung-Hyuk
Kim, Chul-Tae
Hawkes, Richard
[J]. CEREBELLUM, 2008, 7 (03): : 295 - 303
[3] TRH receptor agonists ameliorate 3-acetylpyridine-induced ataxia through NMDA receptors in rats
Kinoshita, K
Watanabe, Y
Yamamura, M
Matsuoka, Y
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1998, 343 (2-3) : 129 - 133
[4] Gamma-aminobutyric acid (GABA)-B receptor 1 in cerebellar cortex of essential tremor
Luo, C.
Rajput, A. H.
Robinson, C. A.
Rajput, A.
[J]. JOURNAL OF CLINICAL NEUROSCIENCE, 2012, 19 (06) : 920 - 921
[5] TGF-β1 Provides Neuroprotection via Inhibition of Microglial Activation in 3-Acetylpyridine-Induced Cerebellar Ataxia Model Rats
Cao, Bei-Bei
Zhang, Xiao-Xian
Du, Chen-Yu
Liu, Zhan
Qiu, Yi-Hua
Peng, Yu-Ping
[J]. FRONTIERS IN NEUROSCIENCE, 2020, 14
[6] TGF-β1 PROVIDES NEUROPROTECTION VIA INHIBITION OF MICROGLIAL ACTIVATION IN 3-ACETYLPYRIDINE-INDUCED CEREBELLAR ATAXIA MODEL RATS
Cao, B-B.
Liu, Z.
Peng, Y-P.
[J]. PARKINSONISM & RELATED DISORDERS, 2024, 122
[7] Neuroprotective effects of the GABA(A) receptor partial agonist U-101017 in 3-acetylpyridine-treated rats
Sethy, VH
Wu, HY
Oostveen, JA
Hall, ED
[J]. NEUROSCIENCE LETTERS, 1997, 228 (01) : 45 - 49
[8] Decreased GABA Receptor Binding in the Cerebral Cortex of Insulin Induced Hypoglycemic and Streptozotocin Induced Diabetic Rats
Antony, Sherin
Kumar, T. Peeyush
Kuruvilla, Korah P.
George, Naijil
Paulose, C. S.
[J]. NEUROCHEMICAL RESEARCH, 2010, 35 (10) : 1516 - 1521
[9] Decreased GABA Receptor Binding in the Cerebral Cortex of Insulin Induced Hypoglycemic and Streptozotocin Induced Diabetic Rats
Sherin Antony
T. Peeyush Kumar
Korah P. Kuruvilla
Naijil George
C. S. Paulose
[J]. Neurochemical Research, 2010, 35 : 1516 - 1521
[10] Co-treatment with riluzole, a neuroprotective drug, ameliorates the 3-acetylpyridine-induced neurotoxicity in cerebellar Purkinje neurones of rats: Behavioural and electrophysiological evidence
Janahmadi, Mahyar
Goudarzi, Iran
Kaffashian, Mohammad Reza
Behzadi, Gila
Fathollahi, Yaqub
Hajizadeh, Sohrab
[J]. NEUROTOXICOLOGY, 2009, 30 (03) : 393 - 402

← 1 2 3 4 5 →