SEQUENCE OF THE 5'-FLANKING REGION OF THE RAT C-FOS PROTOONCOGENE

被引：27
|
作者：
WANG, WW
HOWELLS, RD
机构：
[1] UNIV MED & DENT NEW JERSEY,NEW JERSEY MED SCH,DEPT BIOCHEM & MOLEC BIOL,NEWARK,NJ 07103
[2] UNIV MED & DENT NEW JERSEY,GRAD SCH BIOMED SCI,NEWARK,NJ 07103
来源：
GENE | 1994年 / 143卷 / 02期
关键词：
IMMEDIATE-EARLY GENE; GENE REGULATION; TRANSCRIPTION FACTOR; AP-1; ENHANCER; RESPONSE ELEMENT;
D O I：
10.1016/0378-1119(94)90107-4
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The proto-oncogene c-fos is an immediate-early gene that becomes activated by a wide variety of extracellular stimuli. Since many studies regarding regulation of c-fos are conducted in vivo using rats, or with rat cell lines, we have cloned the rat c-fos gene in order to verify that the same regulatory elements that have been characterized in the human and mouse c-fos promoter are also present and functional in the rat. The nucleotide (nt) sequence of the 5'-flanking region of the rat c-fos gene displays remarkable similarity with the mouse and human c-fos genes (93 and 77% identity, respectively). cis-Acting regulatory elements, such as the sis-inducible element element (SIE), serum-response element (SRE), AP-1-recognition site, calcium/cAMP-response element (Ca/CRE) and TATA box are present in the rat c-fos 5'-flanking region. A putative glucocorticoid-response element (GRE) is present 13 bp downstream from the AP-1-recognition site.
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页码：261 / 264
页数：4
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