INHIBITORY EFFECTS OF PHENOLIC-COMPOUNDS ON CCL4-INDUCED MICROSOMAL LIPID-PEROXIDATION

被引：256
|
作者：
CHOLBI, MR
PAYA, M
ALCARAZ, MJ
机构：
[1] Departamento de Farmacologia y Farmacotecnia, Facultad de Farmacia, Valencia, E-46010
来源：
EXPERIENTIA | 1991年 / 47卷 / 02期
关键词：
PHENOLIC COMPOUNDS; CCL4-INDUCED PEROXIDATION; TBA-REACTIVE SUBSTANCES;
D O I：
10.1007/BF01945426
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The antiperoxidative effects of 35 phenolic compounds, most of them belonging to the flavonoid class, were investigated using CCl4-induced peroxidation of rat liver microsomes. This system was rather insensitive to gallic acid, methyl gallate and ellagic acid. Nevertheless it was inhibited by flavonoids and structure/activity relationships were established. The most potent compounds were gardenin D, luteolin, apigenin (flavones), datiscetin, morin, galangin (flavonols), eriodictyol (flavanone), amentoflavone (biflavone) and the reference compound, (+)-catechin. The natural polymethoxyflavone gardenin D has shown a potency comparable to that of (+)-catechin and higher than that of silybin. Thus, it may be considered as a new type of natural antioxidant with potential therapeutical applications.
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页码：195 / 199
页数：5
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