Formulation and Evaluation of Transdermal Ondansetron Hydrochloride Matrix Patch: In Vitro Skin Permeation and Irritation Study

In the present study an attempt was made to develop a suitable matrix type transdermal patch of ondansetron hydrochloride using blends of two different type of polymeric combinations viz. PVP and HPMC K4 M and Eudragit L100 with Povidone (PVP). The prepared formulations were subjected to various physiochemical evaluation test like moisture content loss, moisture absorption, flatness to study the stability of the formulations, in vitro dissolution was performed to determine the amount of ondansetron hydrochloride present in the patches. Drug-excipient interaction studies were carried out using Fourier transform infrared (FTIR) spectroscopy technique. In vitro skin permeation study was conducted in a modified Franz's diffusion cell. The in vitro release of the drug from the formulations was studied using commercial semi permeable membrane. All the formulations were found to be suitable for formulating in terms of physiochemical characteristics and there was no notification in significant interaction between the drug and polymer used. In vitro dissolution data showed that formulation of PVP: HPMC K4 M showed faster release of drug than the PVP: Eudragit L100 formulations during skin permeation studies. Skin irritation studies revealed that the batch containing PVP-Eudragit L100 has no erythema and oedema. Based on the observation, we can reveal that PVP-eudragit L100 polymers are better suited than PVP-HPMC K4 M polymer for the development of ondansetron hydrochloride transdermal patches.