ACTIVATION OF GLUTAMATE METABOTROPIC RECEPTORS INDUCES LONG-TERM POTENTIATION

被引：88

作者：

BORTOLOTTO, ZA ^{[1
]}

COLLINGRIDGE, GL ^{[1
]}

机构：

[1] UNIV BIRMINGHAM,SCH MED,DEPT PHARMACOL,BIRMINGHAM B15 2TT,W MIDLANDS,ENGLAND

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 214卷 / 2-3期

基金：

英国医学研究理事会;

关键词：

1S; 3R-ACPD; (1S; 3R-AMINOCYCLOPENTANE DICARBOXYLATE); METABOTROPIC RECEPTORS; LONG-TERM POTENTIATION (LTP);

D O I：

10.1016/0014-2999(92)90135-Q

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The specific glutamate metabotropic receptor agonist 1S,3R-aminocyclopentane dicarboxylate (ACPD), but not its inactive enantiomer 1R,3S-ACPD, induced a slowly developing potentiation of synaptic transmission in rat hippocampal slices. This effect was independent of its ability to potentiate responses mediated by the activation of N-methyl-D-aspartate receptors. Perfusion with 1S,3R-ACPD provides, therefore, a means of chemically inducing a form of long-term potentiation.

引用

页码：297 / 298

页数：2

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