ANIMAL-MODELS OF HUMAN GENETIC-DISEASES

被引：87
|
作者：
SMITHIES, O
机构：
[1] Department of Pathology, University of North Carolina at Chapel Hill, Chapel Hill
来源：
TRENDS IN GENETICS | 1993年 / 9卷 / 04期
关键词：
D O I：
10.1016/0168-9525(93)90204-U
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Gene targeting in cultured embryonic stem cells permits the generation of mice with a desired alteration in a chosen target gene. Application of this procedure to create mouse models of human diseases is revealing the innate complexity of diseases normally ascribed to single gene defects. Modeling human diseases that are known to be multigenic in origin and are markedly influenced by environmental factors is potentially even more revealing.
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页码：112 / 117
页数：6
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