RAPID TURNOVER OF PLASMA VIRIONS AND CD4 LYMPHOCYTES IN HIV-1 INFECTION

被引：3669
|
作者：
HO, DD
NEUMANN, AU
PERELSON, AS
CHEN, W
LEONARD, JM
MARKOWITZ, M
机构：
[1] SANTA FE INST,SANTA FE,NM 87501
[2] LOS ALAMOS NATL LAB,DIV THEORET,LOS ALAMOS,NM 87545
[3] ABBOTT LABS,DIV PHARMACEUT PROD,ABBOTT PK,IL 60064
来源：
NATURE | 1995年 / 373卷 / 6510期
关键词：
D O I：
10.1038/373123a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Treatment of infected patients with ABT-538, an inhibitor of the protease of human immunodeficiency virus type 1 (HIV-1), causes plasma HIV-1 levels to decrease exponentially (mean half-life, 2.1 +/- 0.4 days) and CD4 lymphocyte counts to rise substantially. Minimum estimates of HIV-1 production and clearance and of CD4 lymphocyte turnover indicate that replication of HIV-1 in vivo is continuous and highly productive, driving the rapid turnover of CD4 lymphocytes.
引用
收藏
页码：123 / 126
页数：4
相关论文
共 50 条
  • [1] HOT PAPERS - AIDS RESEARCH - RAPID TURNOVER OF PLASMA VIRIONS AND CD4 LYMPHOCYTES IN HIV-1 INFECTION - BY HO,D.D. ETAL - COMMENTS
    MARKOWITZ, M
    [J]. SCIENTIST, 1995, 9 (24): : 15 - 15
  • [2] Plasma viral load and CD4(+) lymphocytes as prognostic markers of HIV-1 infection
    Mellors, JW
    Munoz, A
    Giorgi, JV
    Margolick, JB
    Tassoni, CJ
    Gupta, P
    Kingsley, LA
    Todd, JA
    Saah, AJ
    Detels, R
    Phair, JP
    Rinaldo, CR
    [J]. ANNALS OF INTERNAL MEDICINE, 1997, 126 (12) : 946 - 954
  • [3] CYTOTOXIC T-LYMPHOCYTES THAT KILL AUTOLOGOUS CD4(+) LYMPHOCYTES ARE ASSOCIATED WITH CD4(+) LYMPHOCYTE DEPLETION IN HIV-1 INFECTION
    GRANT, MD
    SMAIL, FM
    ROSENTHAL, KL
    [J]. JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY, 1994, 7 (06): : 571 - 579
  • [4] VIROLOGICAL ANALYSIS OF PRIMARY HIV-1 INFECTION WITH RAPID CD4 DEPLETION
    LAFEUILLADE, A
    TAMALET, C
    DEMICCO, P
    THIEBAUT, C
    [J]. AIDS, 1995, 9 (12) : 1380 - 1381
  • [5] Vpr content of HIV-1 virions determines infection of resting peripheral blood CD4+ lymphocytes
    Anouk Van Nuffel
    Francis Impens
    Ann Baeyens
    Stijn Vanhee
    Wojciech Witkowski
    Elien Vandermarliere
    Hanne Vanderstraeten
    Evelien Naessens
    Kathleen Vanlandeghem
    Sophie Vermaut
    Kathleen Moens
    Petra Van Damme
    Kris Gevaert
    Bruno Verhasselt
    [J]. Retrovirology, 10
  • [6] Vpr content of HIV-1 virions determines infection of resting peripheral blood CD4+ lymphocytes
    Van Nuffel, Anouk
    Impens, Francis
    Baeyens, Ann
    Vanhee, Stijn
    Witkowski, Wojciech
    Vandermarliere, Elien
    Vanderstraeten, Hanne
    Naessens, Evelien
    Vanlandeghem, Kathleen
    Vermaut, Sophie
    Moens, Kathleen
    Van Damme, Petra
    Gevaert, Kris
    Verhasselt, Bruno
    [J]. RETROVIROLOGY, 2013, 10 : S32 - S33
  • [7] Modeling the dynamics of HIV-1 and CD4 and CD8 lymphocytes
    de Souza, FMC
    de Mendonca, RN
    [J]. IEEE ENGINEERING IN MEDICINE AND BIOLOGY MAGAZINE, 1999, 18 (01): : 21 - 24
  • [8] HIV-1 INFECTION ABOLISHES CD4 BIOSYNTHESIS BUT NOT CD4 MESSENGER-RNA
    YUILLE, MAR
    HUGUNIN, M
    JOHN, P
    PEER, L
    SACKS, LV
    POIESZ, BJ
    TOMAR, RH
    SILVERSTONE, AE
    [J]. JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY, 1988, 1 (02): : 131 - 137
  • [9] SOLUBLE CD4 DURING HUMAN HIV-1 INFECTION
    DEPAOLI, P
    BASAGLIA, G
    GENNARI, D
    JUS, A
    CROVATTO, M
    SANTINI, G
    [J]. INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY, 1991, 4 (01) : 61 - 65
  • [10] RELATIONSHIP OF CD4 LEVEL TO PROGRESSION OF HIV-1 INFECTION
    ALEDORT, LM
    [J]. THROMBOSIS AND HAEMOSTASIS, 1991, 65 (06) : 1164 - 1164
12345