HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ASSAY FOR IBUPROFEN IN WHOLE-BLOOD USING SOLID-PHASE EXTRACTION

被引：14
|
作者：
SOCHOR, J
KLIMES, J
ZAHRADNICEK, M
SEDLACEK, J
机构：
[1] CHARLES UNIV,FAC PHARM,DEPT PHARMACEUT CHEM & DRUG CONTROL,CR-50165 HRADEC KRALOVE,CZECH REPUBLIC
[2] CHARLES UNIV,FAC MED,DEPT PATHOL PHYSIOL,CR-50000 HRADEC KRALOVE,CZECH REPUBLIC
来源：
JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS | 1994年 / 654卷 / 02期
关键词：
D O I：
10.1016/0378-4347(94)00018-2
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A precise, accurate, reproducible one-step method for the high-performance chromatographic determination of ibuprofen in whole blood is described. Samples were, after haemolysis, prepared by solid-phase extraction. Analyses were performed using reversed-phase chromatography on a Separon SGX C-18 column with a mobile phase of methanol-water (pH 3) and ultraviolet detection at 222 nm. The method was used for pharmacokinetic studies in rabbits.
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页码：282 / 286
页数：5
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