Roles of Education and IQ in Cognitive Reserve in Parkinson's Disease-Mild Cognitive Impairment

被引：34
|
作者：
Armstrong, M. J. [1 ,2 ,3 ]
Naglie, G. [4 ,5 ,6 ]
Duff-Canning, S. [7 ]
Meaney, C. [8 ]
Gill, D.
Eslinger, P. J. [9 ]
Zadikoff, C. [10 ]
Mapstone, M. [11 ]
Chou, K. L. [12 ]
Persad, C. [13 ]
Litvan, I. [14 ]
Mast, B. T. [15 ]
Fox, S. [1 ,2 ,3 ]
Tang-Wai, D. F. [3 ,16 ]
Marras, C. [3 ]
机构：
[1] Univ Toronto, Toronto Western Hosp, Movement Disorders Ctr, Toronto, ON, Canada
[2] Univ Toronto, Edmond J Safra Program Parkinsons Dis, Toronto, ON, Canada
[3] Univ Toronto, Dept Med Neurol, Toronto, ON, Canada
[4] Univ Toronto, Dept Med, Toronto, ON, Canada
[5] Univ Toronto, Rotman Res Inst, Baycrest Geriatr Hlth Care Ctr, Toronto, ON, Canada
[6] Univ Toronto, Inst Hlth Policy Management & Evaluat, Toronto, ON, Canada
[7] Univ Toronto, Toronto Western Hosp, Dept Neuropsychol, Toronto, ON, Canada
[8] Univ Toronto, Dept Family & Community Med, Toronto, ON, Canada
[9] Penn State Hershey, Dept Neurol, Hershey, PA USA
[10] Northwestern Univ, Dept Neurol, Evanston, IL USA
[11] Univ Rochester, Dept Neurol, Rochester, NY USA
[12] Dept Neurol, Ann Arbor, MI USA
[13] Dept Psychiat, Ann Arbor, MI USA
[14] Univ Calif San Diego, Dept Neurol, San Diego, CA 92103 USA
[15] Univ Louisville, Psychol & Brain Sci, Louisville, KY 40292 USA
[16] Univ Toronto, Div Neurol, Univ Hlth Network Memory Clin, Toronto, ON, Canada
来源：
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS EXTRA | 2012年 / 2卷 / 01期
基金：
加拿大健康研究院;
关键词：
Parkinson's disease; Mild cognitive impairment; Education; IQ; Cognitive reserve;
D O I：
10.1159/000341782
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Background/Aims: The role of cognitive reserve in Parkinson's disease (PD)-mild cognitive impairment (MCI) is incompletely understood. Methods: The relationships between PD-MCI, years of education, and estimated premorbid IQ were examined in 119 consecutive non-demented PD patients using logistic regression models. Results: Higher education and IQ were associated with reduced odds of PD-MCI in univariate analysis. In multivariable analysis, a higher IQ was associated with a significantly decreased odds of PD-MCI, but education was not. Conclusion: The association of higher IQ and decreased odds of PD-MCI supports a role for cognitive reserve in PD, but further studies are needed to clarify the interaction of IQ and education and the impact of other contributors such as employment and hobbies. Copyright (C) 2012 S. Karger AG, Basel
引用
收藏
页码：343 / 352
页数：10
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