PRELIMINARY STRUCTURAL-ANALYSIS OF THE MUTATIONS SELECTED BY NONNUCLEOSIDE INHIBITORS OF HIV-1 REVERSE-TRANSCRIPTASE

被引：13
|
作者：
TONG, L
CARDOZO, M
JONES, PJ
ADAMS, J
机构：
[1] BOEHRINGER INGELHEIM PHARMACEUT INC,DEPT MED CHEM,900 RIDGEBURY RD,RIDGEFIELD,CT 06877
[2] BOEHRINGER INGELHEIM PHARMACEUT INC,DEPT ANALYT SCI,RIDGEFIELD,CT 06877
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 04期
关键词：
D O I：
10.1016/S0960-894X(01)81262-2
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The crystal structure of HIV reverse transcriptase complexed with nevirapine showed that most of the mutations that confer resistance to non-nucleoside inhibitors of RT are clustered around the nevirapine binding pocket. Establishment of favorable interactions with conserved residues in this pocket is essential for the design of second generation RT inhibitors.
引用
收藏
页码：721 / 726
页数：6
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