THE GENETIC-BASIS OF HYPERTROPHIC CARDIOMYOPATHY

被引：5
|
作者：
ELSTEIN, E [1 ]
LIEW, CC [1 ]
SOLE, MJ [1 ]
机构：
[1] UNIV TORONTO, CTR CARDIOVASC RES, TORONTO M5S 1A1, ONTARIO, CANADA
来源：
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY | 1992年 / 24卷 / 12期
关键词：
HYPERTROPHIC CARDIOMYOPATHY; GENETICS; MOLECULAR BIOLOGY; MUTATIONS;
D O I：
10.1016/0022-2828(92)91087-L
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In this article we review the techniques of molecular biology as they apply to the elucidation of the genetic basis of hypertrophic cardiomypathy. We review the evidence for linkage to chromosome 14 and the specific mutations described to date. The evidence for genetic heterogeneity is presented. We speculate on the pathophysiology of the disease from the perspective of the known molecular defects and review the clinical implications the evolving information may have. © 1992.
引用
收藏
页码：1471 / 1477
页数：7
相关论文
共 50 条
  • [1] Molecular Genetic Basis of Hypertrophic Cardiomyopathy
    Marian, A. J.
    [J]. CIRCULATION RESEARCH, 2021, 128 (10) : 1533 - 1553
  • [2] Genetic basis of hypertrophic cardiomyopathy in children
    Stefan Rupp
    Moataz Felimban
    Anne Schänzer
    Dietmar Schranz
    Christoph Marschall
    Martin Zenker
    Thushiha Logeswaran
    Christoph Neuhäuser
    Josef Thul
    Christian Jux
    Andreas Hahn
    [J]. Clinical Research in Cardiology, 2019, 108 : 282 - 289
  • [3] The genetic basis of hypertrophic and dilated cardiomyopathy
    Thierfelder, L
    [J]. JOURNAL OF PATHOLOGY, 2000, 190 : 62A - 62A
  • [4] Genetic Basis of Hypertrophic Cardiomyopathy in Cats
    Grzeczka, Arkadiusz
    Graczyk, Szymon
    Paslawski, Robert
    Paslawska, Urszula
    [J]. CURRENT ISSUES IN MOLECULAR BIOLOGY, 2024, 46 (08) : 8752 - 8766
  • [5] Genetic basis of hypertrophic cardiomyopathy in children
    Rupp, Stefan
    Felimban, Moataz
    Schaenzer, Anne
    Schranz, Dietmar
    Marschall, Christoph
    Zenker, Martin
    Logeswaran, Thushiha
    Neuhaeuser, Christoph
    Thul, Josef
    Jux, Christian
    Hahn, Andreas
    [J]. CLINICAL RESEARCH IN CARDIOLOGY, 2019, 108 (03) : 282 - 289
  • [6] The molecular genetic basis for hypertrophic cardiomyopathy
    Marian, AJ
    Roberts, R
    [J]. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2001, 33 (04) : 655 - 670
  • [7] Genetic Basis of Heart Transplanted Hypertrophic Cardiomyopathy
    Garcia-Pavia, P.
    Segovia, J.
    Vazquez, M. E.
    Salas, C.
    Avellana, P.
    Gomez-Bueno, M.
    Gallardo, E.
    Garcia-Cosio Carmena, M. D.
    Cobo-Marcos, M.
    Vilches, C.
    Garesse, R.
    Molano, J.
    Bornstein, B.
    Alonso Pulpon, L. A.
    [J]. JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2011, 30 (04): : S135 - S135
  • [8] The genetic basis of hypertrophic cardiomyopathy in cats and humans
    Kittleson, Mark D.
    Meurs, Kathryn M.
    Harris, Samantha P.
    [J]. JOURNAL OF VETERINARY CARDIOLOGY, 2015, 17 : S53 - S73
  • [9] THE GENETIC-BASIS OF DWARFISM
    FRANCOMANO, CA
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1995, 332 (01): : 58 - 59
  • [10] GENETIC-BASIS FOR TRANSSEXUALISM
    CRICHTON, P
    [J]. BRITISH JOURNAL OF PSYCHIATRY, 1993, 162 : 569 - 569
12345