CYCLODEXTRIN CHIRAL STATIONARY PHASES FOR LIQUID-CHROMATOGRAPHIC SEPARATIONS OF DRUG STEREOISOMERS

被引：66
|
作者：
BERTHOD, A [1 ]
JIN, HL [1 ]
BEESLEY, TE [1 ]
DUNCAN, JD [1 ]
ARMSTRONG, DW [1 ]
机构：
[1] UNIV MISSOURI,DEPT CHEM,ROLLA,MO 65401
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1990年 / 8卷 / 02期
关键词：
Chiral separation; cyclodextrin; liquid chromatography; racemic drugs;
D O I：
10.1016/0731-7085(90)80018-K
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Many active drugs are racemic mixtures. Because the two enantiomers of a racemate often cause different pharmacological responses, the use of optically pure isomers is desirable and may be soon required. Cyclodextrin-bonded silica gel can be used as chiral stationary phase (CSP) in liquid chromatography. The enantiomers of 25 different racemic drugs were separated on such CSPs in the reversed-phase mode. The principal features of the cyclodextrin chiral recognition mechanism are recalled and some information on future trends for cyclodextrin CSPs is provided. © 1990.
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页码：123 / 130
页数：8
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