Does Branched-Chain Amino Acids Supplementation Modulate Skeletal Muscle Remodeling through Inflammation Modulation? Possible Mechanisms of Action

被引:67
|
作者
Nicastro, Humberto [1 ]
da Luz, Claudia Ribeiro [1 ]
Seixas Chaves, Daniela Fojo [1 ]
Grassmann Bechara, Luiz Roberto [2 ]
Voltarelli, Vanessa Azevedo [2 ]
Rogero, Marcelo Macedo [3 ]
Lancha, Antonio Herbert, Jr. [1 ]
机构
[1] Univ Sao Paulo, Sch Phys Educ & Sports, Lab Appl Nutr & Metab, POB 05508-030, Sao Paulo, Brazil
[2] Univ Sao Paulo, Sch Phys Educ & Sports, Lab Mol & Cellular Physiol Exercise, Sao Paulo, Brazil
[3] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, Sao Paulo, Brazil
基金
巴西圣保罗研究基金会;
关键词
D O I
10.1155/2012/136937
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Skeletal muscle protein turnover is modulated by intracellular signaling pathways involved in protein synthesis, degradation, and inflammation. The proinflammatory status of muscle cells, observed in pathological conditions such as cancer, aging, and sepsis, can directly modulate protein translation initiation and muscle proteolysis, contributing to negative protein turnover. In this context, branched-chain amino acids (BCAAs), especially leucine, have been described as a strong nutritional stimulus able to enhance protein translation initiation and attenuate proteolysis. Furthermore, under inflammatory conditions, BCAA can be transaminated to glutamate in order to increase glutamine synthesis, which is a substrate highly consumed by inflammatory cells such as macrophages. The present paper describes the role of inflammation on muscle remodeling and the possible metabolic and cellular effects of BCAA supplementation in the modulation of inflammatory status of skeletal muscle and the consequences on protein synthesis and degradation.
引用
收藏
页数:10
相关论文
共 50 条
  • [1] Dexamethasone blunts the action of branched-chain amino acids (BCAA) on skeletal muscle in humans
    Liu, ZQ
    Fryburg, DA
    Jahn, LA
    Wei, LP
    Barrett, EJ
    DIABETES, 2000, 49 : A28 - A28
  • [2] Nutraceutical effects of branched-chain amino acids on skeletal muscle
    Shimomura, Y
    Yamamoto, Y
    Bajotto, G
    Sato, J
    Murakami, T
    Shimomura, N
    Kobayashi, H
    Mawatari, K
    JOURNAL OF NUTRITION, 2006, 136 (02): : 529S - 532S
  • [3] Branched-chain amino acids inhibit proteolysis in rat skeletal muscle:: Mechanisms involved
    Busquets, S
    Alvarez, B
    Llovera, M
    Agell, N
    López-Soriano, FJ
    Argilés, JM
    JOURNAL OF CELLULAR PHYSIOLOGY, 2000, 184 (03) : 380 - 384
  • [4] Coordinated Modulation of Energy Metabolism and Inflammation by Branched-Chain Amino Acids and Fatty Acids
    Ye, Zhenhong
    Wang, Siyu
    Zhang, Chunmei
    Zhao, Yue
    FRONTIERS IN ENDOCRINOLOGY, 2020, 11
  • [5] Update on nutritional supplementation with branched-chain amino acids
    Bianchi, G
    Marzocchi, R
    Agostini, F
    Marchesini, G
    CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE, 2005, 8 (01): : 83 - 87
  • [6] Branched-chain amino acids:: A role in skeletal muscle proteolysis in catabolic states?
    Busquets, S
    Alvarez, B
    López-Soriano, FJ
    Argilés, JM
    JOURNAL OF CELLULAR PHYSIOLOGY, 2002, 191 (03) : 283 - 289
  • [7] Is Branched-Chain Amino Acids Supplementation an Efficient Nutritional Strategy to Alleviate Skeletal Muscle Damage? A Systematic Review
    Foure, Alexandre
    Bendahan, David
    NUTRIENTS, 2017, 9 (10)
  • [8] REGULATORY MECHANISMS IN BIOSYNTHESIS OF BRANCHED-CHAIN AMINO ACIDS
    UMBARGER, HE
    BIOCHEMICAL JOURNAL, 1964, 90 (02) : P22 - &
  • [9] Supplementation with branched-chain amino acids improves muscle mass of cirrhotic patients with sarcopenia
    Hernandez Conde, Marta
    Llop, Elba
    Tormo, Beatriz
    Perello, Christie
    Lopez-Gomez, Marta
    Abad Guerra, Javier
    Rodriguez, Luis
    Martinez Porras, Jose Luis
    Fernandez Puga, Natalia
    Ferre, Carlos
    Trapero, Maria
    Fraga, Enrique
    Calleja Panero, Jose Luis
    JOURNAL OF HEPATOLOGY, 2020, 73 : S37 - S38
  • [10] Creatine Supplementation Increases Muscle Branched-Chain Amino Acids in an Alzheimer Mouse Model
    Farshidfar, Farnaz
    Suh, Miyoung
    Snow, Wanda
    Albensi, Benedict
    Myrie, Semone
    FASEB JOURNAL, 2015, 29