OLEIC-ACID - A MEMBRANE FLUIDIZER OR FLUID WITHIN THE MEMBRANE

被引：45
|
作者：
WALKER, M
HADGRAFT, J
机构：
[1] UNIV WALES COLL CARDIFF, WELSH SCH PHARM, CARDIFF CF1 3XF, WALES
[2] SQUIBB DERM, DEESIDE CH5 2NU, CLWYD, WALES
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1991年 / 71卷 / 1-2期
关键词：
OLEIC ACID; STRATUM CORNEUM; PENETRATION ENHANCER; INTERCELLULAR LIPID;
D O I：
10.1016/0378-5173(91)90078-3
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Studies have been conducted that propose a mechanism of action for the penetration enhancer oleic acid (OA). The normal intercellular lipid arrangement of the stratum corneum may be disrupted by the introduction of 'fluid-like OA channels' within the corneum lipids at physiological temperatures.
引用
收藏
页码：R1 / R4
页数：4
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