Comparison of Computational Tools for Protein-Protein Interaction (PPI) Mapping and Analysis

被引：0
|
作者：
Leong, Geok Wei [1 ]
Lee, Sheau Chen [1 ]
Lau, Cher Chien [1 ]
Klappa, Peter [2 ]
Shamsir, Mohd Shahir [1 ]
机构：
[1] Univ Teknol Malaysia, Fac Biosci & Med Engn, Dept Biotechnol & Med Engn, Utm Johor Bahru 81310, Johor, Malaysia
[2] Univ Kent, Canterbury, Kent, England
来源：
JURNAL TEKNOLOGI | 2013年 / 63卷 / 01期
关键词：
Visualization tools; protein-protein interaction network; system biology; proteomic database; protein mining; protein mapping;
D O I：
暂无
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Several visualization tools for the mapping of protein-protein interactions have been developed in recent years. However, a systematic comparison of the virtues and limitations of different PPI visualization tools has not been carried out so far. In this study, we compare seven commonly used visualization tools, based on input and output file format, layout algorithm, database integration, Gene Ontology annotation and accessibility of each tool. The assessment was carried out based on brain disease datasets. Our suggested tools, NAViGaTOR, Cytoscape and Gephi perform competitively as PPI network visualization tools, can be a reference for future researches on PPI mapping and analysis.
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页数：8
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