P53 MUTATIONS IN BREAST-CANCER

被引:0
|
作者
COLES, C
CONDIE, A
CHETTY, U
STEEL, CM
EVANS, HJ
PROSSER, J
机构
[1] WESTERN GEN HOSP,MRC,HUMAN GENET UNIT,EDINBURGH EH4 2XU,MIDLOTHIAN,SCOTLAND
[2] ROYAL INFIRM,DEPT SURG,EDINBURGH EH3 9YU,SCOTLAND
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中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
We have identified and analyzed 41 mutations in p53 in sporadic breast tumors from 136 unselected breast cancer patients and estimate that approximately 40% of such tumors contain p53 mutations. The frequency of G-T transversions and the incidence of guanosine mutations in the nontranscribed strand of the p53 gene were found to be higher than expected, and we suggest, therefore, that exogenous carcinogens have an etiological role in sporadic breast cancers. Mutations were recorded in 44 codons of the p53 gene, with no obvious mutational hot-spots, although mutations at codons 175, 194, 273, and 280 accounted for 25% of the changes. One germ-line mutation was found in 136 patients and so we conclude that constitutional mutation of p53 may be an uncommon etiological factor in breast cancer.
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页码:5291 / 5298
页数:8
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