Study of Foeniculum vulgare (Fennel) Seed Extract Effects on Serum Level of Oxidative Stress

Objective: The Foeniculum vulgare (FVE), known as fennel, has a long history of herbal uses as both food and medicine. The seed of this plant has been used to promote menstruation, alleviate the symptoms of female climacteric, and increase the number of ovarian follicles. The aim of this study was to evaluate the fennel extract effects on serum level of oxidative stress in female mice. Materials and Methods: Totally, 28 virgin female albino mice were divided into four groups (n = 7). Groups 1 and 2 (experimental groups) were administered FVE at 100 and at a concentration of 100 and 200 mg/kg for 5 days, interaperitoneally. Group 3 (negative control) received ethanol and Group 4 (positive control) received normal saline. Animals were scarified at 6th day, sera were collected and the level of oxidative stress was determination of using total antioxidant status kit. Results: Data analysis revealed that there is a significant difference in the mean level of serum oxidative stress between four different groups. P value in experimental groups compared to the control group was (P < 0.0001). Conclusion: Fennel extract can decrease the serum level of oxidative factors in female mice; it can be introduced as a novel medicine for treatment of infertility