INHIBITION OF MOUSE SKIN TUMOR PROMOTION BY TENUAZONIC ACID

被引：9
|
作者：
ANTONY, M
GUPTA, KP
JANARDANAN, KK
MEHROTRA, NK
机构：
[1] Laboratory of Environmental Carcinogenesis, Industrial Toxicology Research Centre, Lucknow, 226 001, Mahatma Gandhi Marg
来源：
CANCER LETTERS | 1991年 / 61卷 / 01期
关键词：
TENUAZONIC ACID; 12-O-TETRADECANOYL PHORBOL-13-ACETATE; ORNITHINE DECARBOXYLASE; TUMOR PROMOTION;
D O I：
10.1016/0304-3835(91)90072-P
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Tenuazonic acid (TA) was topically applied to the interscapular region of Swiss albino mice at different doses before the application of 12-O-tetradecanoyl phorbol-13-acetate (TPA). Skin from the painted area was examined for ornithine decarboxylase (ODC) enzyme estimation [1]. It was observed that TA inhibited TPA induced ODC activity. The inhibitory effect of TA was also found in mouse skin tumor promotion in the two stage initiation promotion protocol. There was a remarkable delay in the latency period and decrease in the number of tumors developed and the percentage of tumor bearing animals after TA treatment.
引用
收藏
页码：21 / 25
页数：5
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