RECEPTOR-MEDIATED CALCIUM ENTRY

被引：137

作者：

RINK, TJ ^{[1
]}

机构：

[1] PHYSIOL LAB, CAMBRIDGE CB2 3EG, ENGLAND

来源：

FEBS LETTERS | 1990年 / 268卷 / 02期

关键词：

Ca[!sup]2+[!/sup; Endothelium; Fura-2; Mn[!sup]2+[!/sup; Patch-clamp; Platelet;

D O I：

10.1016/0014-5793(90)81290-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Occupation of membrane receptors can evoke calcium signals by causing depolarisation and activating voltage-operated calcium channels, by triggering internal release, or by stimulating calcium influx processes not gated by membrane potential, receptor-mediated calcium entry, RCME. This brief review considers different possible coupling mechanisms and the proposal that entry can occur from external medium to intracellular store, by-passing the cytosol, and regulated by the state of filling of the store. Recent studies using Mn2+ as a probe for RCME are outlined, as are some new electrophysiologic measurements with human platelets and investigations of a novel blocker of RMCE, SK&F 96365. © 1990.

引用

页码：381 / 385

页数：5

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