EVIDENCE FOR A CENTRAL COMPONENT IN THE CARDIOVASCULAR EFFECTS OF CALCIUM-CHANNEL BLOCKERS

被引：7

作者：

ROYCHOWDHARY, AK ^{[1
]}

GURTU, S ^{[1
]}

DHAWAN, KN ^{[1
]}

SINHA, JN ^{[1
]}

GUPTA, GP ^{[1
]}

机构：

[1] KING GEORGE V MEM HOSP, DEPT PHARMACOL & THERAPEUT, LUCKNOW 226003, UTTAR PRADESH, INDIA

来源：

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY | 1991年 / 17卷 / 06期

关键词：

CALCIUM ANTAGONISTS; VERAPAMIL; DILTIAZEM; HEART RATE; BLOOD PRESSURE; VAGOTOMY;

D O I：

10.1097/00005344-199106000-00023

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The possibility of a central component in the cardiovascular effects of peripherally administered calcium channel blockers has been explored through a comparison of the effects observed after intravenous (i.v.) and intracisternal (i.c.) administration of verapamil and diltiazem in chloralose-anesthetized and artificially ventilated cats. Both agents produced relatively greater effects after i.c. than after i.v. administration. The bradycardiac effect following i.c. as well as i.v. administration was totally abolished by bilateral cervical vagotomy, and the hypotensive effect was attenuated by this procedure. The results strongly suggest the existence of a central component in the cardiovascular effects of both agents.

引用

页码：1015 / 1018

页数：4

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