Prostate cryoablation is an effective mini-invasive treatment for prostate cancer (PC), which may be used in case of both primary and postradiotherapy recurrent tumor. Due to continuous improvements of cryoablation equipment, the number of treatment-induced complications is small. The studies of long-term cryotherapy outcomes, such as cancer-specific, metastasis-free, and other survival rates, are presently under way. Focal cryoablation of the prostate remains an experimental therapy option.