COMPARATIVE MAPPING OF 9 HUMAN CHROMOSOME-22Q LOCI IN THE LABORATORY MOUSE

被引：28

作者：

BUCAN, M

GATALICA, B

NOLAN, P

CHUNG, A

LEROUX, A

GROSSMAN, MH

NADEAU, JH

EMANUEL, BS

BUDARF, M

机构：

[1] INSERM,U129,INST COCHIN GENET MOLEC,F-75014 PARIS,FRANCE

[2] TEMPLE UNIV,ST CHRISTOPHERS HOSP CHILDREN,SCH MED,DEPT PEDIAT,PHILADELPHIA,PA 19133

[3] JACKSON LAB,BAR HARBOR,ME 04609

[4] CHILDRENS HOSP PHILADELPHIA,PHILADELPHIA,PA 19104

来源：

HUMAN MOLECULAR GENETICS | 1993年 / 2卷 / 08期

关键词：

D O I：

10.1093/hmg/2.8.1245

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We present a comparative map of genes on human chromosome 22q and homologous loci in the mouse genome. Gene order in humans was established using a panel of somatic cell hybrids. Genetic maps spanning homologous segments on three mouse chromosomes were generated using an interspecific backcross. The conserved linkage between human chromosome 22 and mouse chromosome 16 includes two closely linked loci, Comt and Igl-1. The second conserved linkage involves human chromosome 22 and mouse chromosome 11 and contains two genetically and physically linked loci, Lif and Nfh. Finally, conserved synteny involving mouse chromosome 15 and human chromosome 22 spans 30 cM and contains five loci (Acr, Bzrp, Dia-1, II2rb and Pdgfb). Loci within this conserved synteny have been sublocalized to different portions of human chromosome 22. The order of genes on mouse chromosome 15 and human chromosome 22 provides further evidence for chromosomal rearrangements within the conserved synteny that have occurred since the divergence of lineages leading to mice and humans.

引用

页码：1245 / 1252

页数：8

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