Data on the applicability of albendazole in domestic fowl .2. Target animal-tolerance studies

Albendazole (ABZ), similarly to the other benzimidazoles, is less toxic in mammalians. Sensitivity of chickens against the effective agent was studied during a target animal-toxicological study. Four groups of 10 seven weeks old broiler cocks each were treated via an oral probe once with a 20% suspension of ABZ. The doses used in the groups were 10, 30 and 50 mg/kg of body-mass, the fourth group served as an untreated control. Blood samples were collected before treatment and 6, 24, 48 and 72 hours after treatment to determine the clinicopathological parameters (haemoglobin content, packed cell volume, prothrombin clotting time, aspartate-aminotransferase, lactic acid-dehydrogenase and alkalic phosphatase activities, calcium, inorganic phosphate, sodium, potassium, chloride, creatinine, glucose, total protein, albumin and globulin concentrations, Figs 1 to 5). Clinical symptoms did not develop due to the treatment. Significant changes caused by the treatment were neither found in any of the clinicochemical parameters. Even the five times higher than the proposed therapeutical dose (10 mg/kg of body-mass) proved to be innocuous in chickens.