SYNTHESIS OF POTENTIAL GAMMA-LACTAM ANTIBIOTICS

被引：2
|
作者：
GERARDIN, P
AHRACH, M
SCHNEIDER, R
HOUILLON, F
LOUBINOUX, B
SPRENG, M
COLIN, JL
机构：
[1] UNIV NANCY 1,CHIM ORGAN LAB 4,F-54506 VANDOEUVRE NANCY,FRANCE
[2] VETOQUINOL,F-70200 LURE,FRANCE
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 14期
关键词：
D O I：
10.1016/0960-894X(95)00259-V
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Synthesis and biological testing of new 2-[4-(2-(2-amino-4-thiazolyl)-(Z)-2-(met acetylamino)-3-ore-2-isoxazolidinyl]-2-aryloxy acetic acids analogs of lactivicin are described. The new products were obtained by addition of cycloserine derivatives on t-butyl 2-aryloxy-2-bromo acetate. Substitution on the aryloxy group modifies its leaving ability and allows different levels of activation of the gamma-lactam ring.
引用
收藏
页码：1467 / 1470
页数：4
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