A PILOT-STUDY ON THE URINARY-EXCRETION OF PORPHYRINS IN HUMAN-POPULATIONS CHRONICALLY EXPOSED TO ARSENIC IN MEXICO

被引：32

作者：

GARCIAVARGAS, GG

GARCIARANGEL, A

AGUILARROMO, M

GARCIASALCEDO, J

DELRAZO, LM

OSTROSKYWEGMAN, P

DENAVA, CC

CEBRIAN, ME

机构：

[1] INST POLITECN NACL, CINVESTAV, DEPT FARMACOL & TOXICOL, POB 14740, MEXICO CITY 07000, MEXICO

[2] UNIV AUTONOMA COAHUILA, FAC MED, TORREON 27000, COAHUILA, MEXICO

[3] NATL AUTONOMOUS UNIV MEXICO, INST INVEST BIOMED, MEXICO CITY 04510, DF, MEXICO

来源：

HUMAN & EXPERIMENTAL TOXICOLOGY | 1991年 / 10卷 / 03期

关键词：

D O I：

10.1177/096032719101000307

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

1 The aim of this pilot study was to investigate if the porphyrinuria produced by arsenic in rodents was present in humans chronically exposed to arsenic via drinking water. 2 The concentrations of uroporphyrin, coproporphyrin and total arsenic in urine were compared between 21 individuals exposed to arsenic in their drinking water (0.390 mg 1(-1)) and 19 controls exposed to 0.012 mg 1(-1). 3 Arsenic-exposed individuals had significantly higher total arsenic concentrations in their urine than the control group. No increase in urinary porphyrin excretion was found in exposed individuals. However, an inversion of the coproporphyrin/uroporphyrin (COPRO/URO) ratio was observed in most exposed individuals. This inversion was caused both, by a decrease in coproporphyrin excretion and an increase in uroporphyrin excretion. 4 No demonstrable correlations between prophyrin excretion, the COPRO/URO ratio and total arsenic concentration in urine were found in exposed individuals.

引用

页码：189 / 193

页数：5

共 30 条

[1] URINARY-EXCRETION OF PORPHYRINS BY SMELTER WORKERS CHRONICALLY EXPOSED TO ARSENIC DUST
TELOLAHY, P
JAVELAUD, B
CLUET, J
DECEAURRIZ, J
BOUDENE, C
TOXICOLOGY LETTERS, 1993, 66 (01) : 89 - 95
[2] ALTERED URINARY PORPHYRIN EXCRETION IN A HUMAN-POPULATION CHRONICALLY EXPOSED TO ARSENIC IN MEXICO
GARCIAVARGAS, GG
DELRAZO, LM
CEBRIAN, ME
ALBORES, A
OSTROSKYWEGMAN, P
MONTERO, R
GONSEBATT, ME
LIM, CK
DEMATTEIS, F
HUMAN & EXPERIMENTAL TOXICOLOGY, 1994, 13 (12): : 839 - 847
[3] LYMPHOCYTE-PROLIFERATION KINETICS AND GENOTOXIC FINDINGS IN A PILOT-STUDY ON INDIVIDUALS CHRONICALLY EXPOSED TO ARSENIC IN MEXICO
OSTROSKYWEGMAN, P
GONSEBATT, ME
MONTERO, R
VEGA, L
BARBA, H
ESPINOSA, J
PALAO, A
CORTINAS, C
GARCIAVARGAS, G
DELRAZO, LM
CEBRIAN, M
MUTATION RESEARCH, 1991, 250 (1-2): : 477 - 482
[4] DETERMINATION OF URINARY-EXCRETION OF CANNABINOIDS USING AN IMMUNOASSAY TECHNIQUE - A PILOT-STUDY
SCHWARTZ, RH
HAYDEN, GF
RIDDLE, M
PEDIATRIC RESEARCH, 1985, 19 (04) : A113 - A113
[5] Alteration in bilirubin excretion in individuals chronically exposed to arsenic in Mexico
Hernández-Zavala, A
Del Razo, LM
Aguilar, C
García-Vargas, GG
Borja, VH
Cebrián, ME
TOXICOLOGY LETTERS, 1998, 99 (02) : 79 - 84
[6] URINARY-EXCRETION OF PORPHYRINS AND PORPHYRIN INTERMEDIATES IN HUMAN ALCOHOLICS
ORTEN, JM
DOEHR, SA
BOND, C
JOHNSON, H
PAPPAS, A
QUARTERLY JOURNAL OF STUDIES ON ALCOHOL, 1963, 24 (04): : 598 - 609
[7] Profile of urinary arsenic metabolites in children chronically exposed to inorganic arsenic in Mexico
Del Razo, LM
García-Vargas, GG
Hernández, MC
Gómez-Muñoz, A
Cebrián, ME
ARSENIC EXPOSURE AND HEALTH EFFECTS, 1999, : 281 - 287
[8] URINARY-EXCRETION OF CATECHOLAMINES IN THYROIDECTOMIZED EUROPEAN HAMSTER CHRONICALLY AND ACUTELY EXPOSED TO COLD
CANGUILHEM, B
MALAN, A
ARCHIVES DES SCIENCES PHYSIOLOGIQUES, 1971, 25 (04) : 517 - +
[9] URINARY FLUORIDE EXCRETION IN SCHOOLCHILDREN EXPOSED TO FLUORIDE AIR-POLLUTION - PILOT-STUDY
ARCHER, DP
GUREKAS, VL
WHITE, FMM
CANADIAN JOURNAL OF PUBLIC HEALTH-REVUE CANADIENNE DE SANTE PUBLIQUE, 1975, 66 (05): : 407 - 410
[10] URINARY-EXCRETION OF MINERAL ARSENIC, METHYLARSONIC ACID AND DIMETHYLARSINIC ACID IN WORKERS EXPOSED TO GALLIUM ARSENIC
NIGNAN, MG
GARNIER, R
AUGER, J
DITCHARLES, D
DOSSIER, E
KLEIN, E
NGUYENAUBIER, D
RENAULT, B
JOURNAL DE TOXICOLOGIE CLINIQUE ET EXPERIMENTALE, 1992, 12 (4-5): : 329 - 331

← 1 2 3 →