SCALE-UP OF AGITATION FLUIDIZED-BED GRANULATION .2. EFFECTS OF SCALE, AIR-FLOW VELOCITY AND AGITATOR ROTATIONAL SPEED ON GRANULE SIZE, SIZE DISTRIBUTION, DENSITY AND SHAPE

被引：0

作者：

WATANO, S

SATO, Y

MIYANAMI, K

MURAKAMI, T

NAGAMI, N

ITO, Y

KAMATA, T

ODA, N

机构：

[1] TAIHO PHARMACEUT CO LTD, TOKUSHIMA 77107, JAPAN

[2] FUJI PAUDAL CO LTD, NERIMA KU, TOKYO 179, JAPAN

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1995年 / 43卷 / 07期

关键词：

SCALE-UP; GRANULATION; AGITATION FLUIDIZED BED; SCALE FACTOR; OPERATING VARIABLE; GRANULE PROPERTY;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Scale-up characteristics of agitation fluidized bed granulation using a pharmaceutical standard formulation was described, The effects of scale, air flow velocity and agitator rotational speed on granule properties such as granule mass median size, size distribution, apparent density and shape factor were investigated experimentally, Based on the results obtained, the effects of these parameters on granule growth and the mechanism of granule formation in different sized equipment were discussed.

引用

页码：1217 / 1220

页数：4

共 4 条

[1] Scale-up of agitation fluidized bed granulation .2. Effects of scale, air flow velocity and agitator rotational speed on granule size, size distribution, density and shape (vol 43, pg 1217, 1995)
Watano, S
CHEMICAL & PHARMACEUTICAL BULLETIN, 1995, 43 (12) : 2279 - 2279
[2] SCALE-UP OF AGITATION FLUIDIZED-BED GRANULATION .3. EFFECTS OF POWDER FEED WEIGHT AND BLADE ANGLE ON GRANULE SIZE, DENSITY AND SHAPE
WATANO, S
SATO, Y
MIYANAMI, K
ITO, Y
KAMATA, T
ODA, N
CHEMICAL & PHARMACEUTICAL BULLETIN, 1995, 43 (07) : 1224 - 1226
[3] SCALE UP CONSIDERATIONS IN FLUIDIZED-BED GRANULATION - AIR-FLOW RATES AND AIR-PRESSURE DISTRIBUTION
CAMPY, D
EAVES, T
GRUDZINSKI, EM
WORTHINGTON, HE
JOURNAL OF PHARMACY AND PHARMACOLOGY, 1974, 26 : P76 - P76
[4] Granulation of Core Particles Suitable for Film Coating by Agitation Fluidized Bed III. Effect of Scale, Agitator Rotational Speed and Blade Shape on Granule Properties and Development of a High Accuracy Scale-Up Theory
Hamashita, Tomohiro
Ono, Tetsuo
Ono, Masaki
Tsunenari, Yoshinobu
Aketo, Takao
Watano, Satoru
CHEMICAL & PHARMACEUTICAL BULLETIN, 2009, 57 (04) : 325 - 331

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