Ultrastructural analysis of the structure and distribution of the adherens junctions in the rats' ventricular myocardium during postnatal stages of ontogeny after the influence of chronic prenatal hypoxia

We have conducted ultrastructural analysis and distribution of the adherens junctions in the rat's ventricles on the 1st, 3rd, 7th, 14th, 30th days during postnatal ontogeny and among mature animals in the normal and after the chronic fetal hypoxia. We found that there is retention of redistribution of the adherens junctions from the lateral surface of the cell to the area of the intercalated disks. The qualitative changes of the desmosomes are characterized by their dystopic location and also at the level of the myofilaments line and there is the appearance of the heteromorphy of the profile length. Morphology of the fascia adherens is characterized by a significant degree of variation: from the direct oblique oriented to the convoluted profiles of junctions. There is a significant dilatation of the intermembrane space area of the fascia adherens in experimental group of rats, which is 303,9% (p<0,05) greater than norm in the left and 37,3% (p<0,05) in the right ventricle in the mature myocardium, and the degree of junction's ectasia in the left ventricle is 216,5% (p<0,05) greater than in the right.