THYROID-HORMONE RESTORES ATRIAL STRETCH-INDUCED SECRETION OF ATRIAL-NATRIURETIC-PEPTIDE IN HYPOPHYSECTOMIZED RATS

被引：5
|
作者：
ZAMIR, N [1 ]
SLOVER, M [1 ]
OHMAN, KP [1 ]
机构：
[1] LINKOPING UNIV HOSP,DEPT INTERNAL MED,S-58185 LINKOPING,SWEDEN
来源：
HORMONE AND METABOLIC RESEARCH | 1993年 / 25卷 / 03期
关键词：
ATRIAL NATRIURETIC PEPTIDE; THYROXINE; ATRIUM; PITUITARY GLAND;
D O I：
10.1055/s-2007-1002066
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Acute blood volume expansion caused a rapid and profound release of atrial natriuretic peptides (ANP) from cardiac atria. The stimulated release of ANP was markedly blunted (more than 50%) in hypophysectomized rats (8 days after surgery). Daily subcutaneous injections of thyroxine (30 mug/kg) to hypophysectomized rats for 7 days, completely restored acute volume expansion induced release of ANP. Our data suggest that thyroid hormone is required for ANP secretion in response to acute volume expansion.
引用
收藏
页码：152 / 155
页数：4
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