INHIBITION OF ALLERGEN-INDUCED BRONCHOCONSTRICTION IN SENSITIZED GUINEA-PIGS BY ORALLY-ADMINISTERED ALLERGEN

被引：5
|
作者：
ISHII, A [1 ]
INO, Y [1 ]
HAIDA, M [1 ]
DOHI, M [1 ]
SUKO, M [1 ]
MORITA, Y [1 ]
ITO, K [1 ]
OKUDAIRA, H [1 ]
机构：
[1] UNIV TOKYO,FAC MED,DEPT MED & PHYS THERAPY,7-3-1 HONGO,BUNKYO KU,TOKYO 113,JAPAN
来源：
INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY | 1991年 / 94卷 / 1-4期
关键词：
D O I：
10.1159/000235386
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Crude mite extract (CME) was orally administered to guinea pigs sensitized to CME. It was shown that such treatment reduces the bronchoconstrictive response upon allergen provocation. Isolated tracheae taken from guinea pigs orally administered CME allergen showed less contraction in response to CME as compared to those obtained from sensitized but not orally treated animals. The oral administration of allergens seemed to attenuate the bronchial hyperresponsiveness of sensitized animals to a non-specific chemical stimulus (histamine). IgE antibodies titrated by 8 days passive cutaneous anaphylaxis, and IgG1 and IgG2 antibodies measured by ELISA were comparable in the sera obtained from animals before and after CME treatment.
引用
收藏
页码：288 / 290
页数：3
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