SEROTONERGIC EXCITATORY DRIVE TO HYPOGLOSSAL MOTONEURONS IN THE DECEREBRATE CAT

被引：187
|
作者：
KUBIN, L
TOJIMA, H
DAVIES, RO
PACK, AI
机构：
[1] UNIV PENN,SCH MED,CTR SLEEP & RESP NEUROBIOL,PHILADELPHIA,PA 19104
[2] UNIV PENN,SCH VET MED,DEPT ANIM BIOL,PHILADELPHIA,PA 19104
来源：
NEUROSCIENCE LETTERS | 1992年 / 139卷 / 02期
关键词：
SEROTONIN; HYPOGLOSSAL MOTONEURON; GENIOGLOSSAL MOTONEURON; DECEREBRATE CAT; SLEEP APNEA; RESPIRATION; UPPER AIRWAY; MICROINJECTION;
D O I：
10.1016/0304-3940(92)90563-M
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
In decerebrate, paralyzed, vagotomized and artificially ventilated cats, serotonin (5-HT) and its analogues, microinjected into the hypoglossal (XII) motor nucleus, altered the activity of the genioglossal branch of XII nerve. 5-HT, carboxamidotryptamine maleate (5-CT) and DOI (1-5 mM) increased the activity by over 200%. Methysergide reversed this increase. Methysergide, mianserin, or ketanserin (100-250 nl, 1 mM) reduced the spontaneous hypoglossal activity by 20-50%. Buspirone, 8-OH-DPAT and (-)-propranolol were without effect. Thus, 5-HT provides a substantial tonic excitatory drive to XII motoneurons. The 5-HT receptors involved are likely to be type 1C or 2, but uncertainty regarding the affinity profiles of the drugs used in in vivo conditions in the cat precludes a definite identification.
引用
收藏
页码：243 / 248
页数：6
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