THE DESIGN, SYNTHESIS AND EVALUATION OF A,C,D-RING ANALOGS OF THE FUNGAL METABOLITE K-76 AS COMPLEMENT INHIBITORS - A POTENTIAL PROBE FOR THE ABSOLUTE STEREOCHEMISTRY AT POSITION-2

被引：12

作者：

KAUFMAN, TS

SRIVASTAVA, RPS

SINDELAR, RD

SCESNEY, SM

MARSH, HC

机构：

[1] UNIV MISSISSIPPI,SCH PHARM,PHARMACEUT SCI RES INST,UNIVERSITY,MS 38677

[2] T CELL SCI INC,CAMBRIDGE,MA 02139

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 05期

关键词：

D O I：

10.1016/0960-894X(95)00061-W

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In an attempt to synthesize stereochemically pure new A, C, D-ring analogs of the natural product complement inhibitor K-76, compounds (20-24) were prepared and the representative one (23) was evaluated for its ability to inhibit complement-mediated erythrocyte lysis in both the classical and alternative pathways. Compounds synthesized as part of this study suggest that the terpenoid diol component of K-76 may not he essential for complement inhibition.

引用

页码：501 / 506

页数：6

共 7 条

[1] DESIGN, SYNTHESIS, AND EVALUATION OF A/C/D-RING ANALOGS OF THE FUNGAL METABOLITE K-76 AS POTENTIAL COMPLEMENT INHIBITORS
KAUFMAN, TS
SRIVASTAVA, RP
SINDELAR, RD
SCESNEY, SM
MARSH, HC
JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (09) : 1437 - 1445
[2] DESIGN, SYNTHESIS AND EVALUATION OF C/D-RING ANALOGS OF THE FUNGAL METABOLITE K-76 AS POTENTIAL COMPLEMENT INHIBITORS
SRIVASTAVA, RP
ZHU, XY
WALKER, LA
SINDELAR, RD
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1995, 5 (15) : 1751 - 1755
[3] SYNTHESIS AND EVALUATION OF B/C/D-RING ANALOGS OF THE ANTI-COMPLEMENT NATURAL PRODUCT K-76
SINDELAR, RD
KAUFMAN, TS
MARSH, HC
SCESNEY, S
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1989, 198 : 35 - MEDI
[4] FURTHER STRUCTURE-ACTIVITY-RELATIONSHIP STUDIES ON A/C/D-RING ANALOGS OF COMPLEMENT INHIBITOR K-76
SRIVASTAVA, RP
ZHU, XY
WALKER, LA
SINDELAR, RD
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1995, 5 (20) : 2429 - 2434
[5] SYNTHESIS OF A/C/D-RING ANALOGS OF THE ANTICOMPLEMENT NATURAL PRODUCT-K-76
KAUFMAN, TS
SINDELAR, RD
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1988, 196 : 364 - ORGN
[6] Synthesis and complement inhibitory activity of B/C/D-ring analogues of the fungal metabolite 6,7-diformyl-3′,4′,4a′,5′,6′,7′,8′,8a′-octahydro-4,6′,7′-trihydroxy-2′,5′,5′,8a′-tetramethylspiro[1′(2′H)-naphthalene-2(3H)-benzofuran]
Bradbury, BJ
Bartyzel, P
Kaufman, TS
Nieto, MJ
Sindelar, RD
Scesney, SM
Gaumond, BR
Marsh, HC
JOURNAL OF MEDICINAL CHEMISTRY, 2003, 46 (13) : 2697 - 2705
[7] Design, synthesis and biological evaluation of novel chromeno[4,3-c] pyrazol-4(2H)-one derivates containing sulfonamido as potential PI3Kα inhibitors
Yin, Yong
Hu, Jia-Qin
Wu, Xu
Sha, Shao
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Qiao, Fang
Song, Zhong-Cheng
Zhu, Hai-Liang
BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 27 (11) : 2261 - 2267

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