INHIBITORY EFFECTS OF PROPIONYL-L-CARNITINE ON PLASMA EXTRAVASATION INDUCED BY IRRITANTS IN RODENTS

The effects of propionyl-L-carnitine (PLC) in various models of inflammation were studied in rats and mice. PLC (50-200 mg/kg i.p.) dose-dependently inhibited the granuloma pouch induced by croton oil in rats, but failed to inhibit either cotton pellet granuloma or carrageenin-induced paw oedema and peritonitis. PLC (100 mg/kg i.p.) significantly reduced mouse ear oedema induced by croton oil, tetradecanoylphorbol acetate and arachidonic acid; in these models, PLC concomitantly reduced plasma extravasation, as evaluated by the leakage of Evans blue. In all the tested models, L-carnitine and acetyl-L-carnitine were ineffective, suggesting a specific protective role of PLC in the vascular component of the inflammatory process.