POLAROGRAPHIC-DETERMINATION OF CLAVULANIC ACID

被引：10
|
作者：
PEREZ, CG
MARTIN, IG
DEALDANA, BRV
机构：
[1] Departamento de Química Analitica, Nutricion y Bromatología, Facultad de Química, Universidad de Salamanca
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1991年 / 9卷 / 05期
关键词：
DIFFERENTIAL-PULSE POLAROGRAPHY; CLAVULANIC ACID;
D O I：
10.1016/0731-7085(91)80161-2
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A method is proposed for the determination of clavulanic acid by differential pulse polarography. The electroactive product was obtained by hydrolysis in sulphuric medium. It shows a reduction peak, that can be used analytically, at -0.75 V (vs SCE). The optimum conditions for the polarographic signal were determined and a study was made of the different parameters affecting the electrochemical process. A polarographic procedure is proposed for the determination of clavulanic acid in a concentration range of 8.0 x 10(-6) - 1.4 x 10(-4) M. The detection limit is about 2 x 10(-6) M and the relative standard deviation is 1.1%. The method was applied to the determination of clavulanic acid in the presence of amoxicillin.
引用
收藏
页码：383 / 386
页数：4
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