THE MECHANISM OF INACTIVATION OF FACTOR-VA BY ACTIVATED PROTEIN-C INVOLVES 2 CLEAVAGES OF THE HEAVY-CHAIN OF THE COFACTOR - (1) ARG(505) AND (2) ARG(306)

被引：0

作者：

KALAFATIS, M ^{[1
]}

MANN, KG ^{[1
]}

机构：

[1] UNIV VERMONT,DEPT BIOCHEM,BURLINGTON,VT 05405

来源：

THROMBOSIS AND HAEMOSTASIS | 1993年 / 69卷 / 06期

关键词：

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：759 / 759

页数：1

共 43 条

[1] MEMBRANE-BOUND HUMAN FACTOR-VA IS INACTIVATED BY ACTIVATED PROTEIN-C AFTER CLEAVAGE OF THE HEAVY-CHAIN AT ARG(506) AND ARG-(306)
KALAFATIS, M
HALEY, PE
MANN, KG
BLOOD, 1993, 82 (10) : A58 - A58
[2] INACTIVATION OF HUMAN FACTOR-VA BY ACTIVATED PROTEIN-C (APC)
TANS, G
ROSING, J
HEEB, MJ
GRIFFIN, JH
THROMBOSIS AND HAEMOSTASIS, 1989, 62 (01) : 167 - 167
[3] ROLE OF THE MEMBRANE IN THE INACTIVATION OF FACTOR-VA BY ACTIVATED PROTEIN-C
KALAFATIS, M
MANN, KG
JOURNAL OF BIOLOGICAL CHEMISTRY, 1993, 268 (36) : 27246 - 27257
[4] The effect of Arg(306) -> Ala and Arg(506) -> Gln substitutions in the inactivation of recombinant human factor Va by activated protein C and protein S
Egan, JO
Kalafatis, M
Mann, KG
PROTEIN SCIENCE, 1997, 6 (09) : 2016 - 2027
[5] Cleavage at both Arg306 and Arg506 is required and sufficient for timely and efficient inactivation of factor Va by activated protein C
Barhoover, Melissa A.
Kalafatis, Michael
BLOOD COAGULATION & FIBRINOLYSIS, 2011, 22 (04) : 317 - 324
[6] Clevage at Both Arg306 and Arg506 Are Required for Timely and Efficient Inactivation of Factor Va by Activated Protein C: Influence of the Assay
Barhoover, Melissa A.
Kalafatis, Michael
BLOOD, 2009, 114 (22) : 836 - 836
[7] Factor Va is inactivated by activated protein C in the absence of cleavage sites at Arg-306, Arg-506, and Arg-679
Kolfschoten, MV
Dirven, RJ
Vos, HL
Tans, G
Rosing, J
Bertina, RM
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (08) : 6567 - 6575
[8] REGULATION OF ACTIVATED PROTEIN-C BY PROTEIN-S - THE ROLE OF PHOSPHOLIPID IN FACTOR-VA INACTIVATION
WALKER, FJ
JOURNAL OF BIOLOGICAL CHEMISTRY, 1981, 256 (21) : 1128 - 1131
[9] LOSS OF PROTHROMBIN AND OF FACTOR-XA-FACTOR-VA INTERACTIONS UPON INACTIVATION OF FACTOR-VA BY ACTIVATED PROTEIN-C
GUINTO, ER
ESMON, CT
JOURNAL OF BIOLOGICAL CHEMISTRY, 1984, 259 (22) : 3986 - 3992
[10] STUDIES OF THE CAPACITY OF FACTOR-XA TO PROTECT FACTOR-VA FROM INACTIVATION BY ACTIVATED PROTEIN-C
NESHEIM, ME
CANFIELD, WM
KISIEL, W
MANN, KG
JOURNAL OF BIOLOGICAL CHEMISTRY, 1982, 257 (03) : 1443 - 1447

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