COMPLEX PATTERNS OF [I-125] OMEGA-CONOTOXIN GVIA BINDING-SITE EXPRESSION DURING POSTNATAL RAT-BRAIN DEVELOPMENT

被引：24
|
作者：
FILLOUX, F
SCHAPPER, A
NAISBITT, SR
OLIVERA, BM
MCINTOSH, JM
机构：
[1] UNIV UTAH,DEPT NEUROL,SALT LAKE CITY,UT 84132
[2] UNIV UTAH,DEPT PSYCHIAT,SALT LAKE CITY,UT 84132
[3] UNIV UTAH,DEPT BIOL,SALT LAKE CITY,UT 84132
[4] UNIV UTAH,DEPT PEDIAT,SALT LAKE CITY,UT 84132
来源：
DEVELOPMENTAL BRAIN RESEARCH | 1994年 / 78卷 / 01期
基金：
美国国家卫生研究院;
关键词：
I-125] OMEGA-CONOTOXIN GVIA; N-TYPE CALCIUM CHANNEL; AUTORADIOGRAPHY; RAT BRAIN DEVELOPMENT;
D O I：
10.1016/0165-3806(94)90017-5
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
In the mature CNS, N-type calcium channels regulate neurotransmitter release. The role of these channels in developing brain is less clear. Study of [I-125]omega-conotoxin GVIA binding sites in developing rat brain using autoradiography reveals that putative N-type channels appear and disappear in complex temporal-spatial profiles including: (1) gradual increase to adult levels (cerebral cortex); (2) substructure differentiation (cerebellum); (3) transient expression (pens); and, (4) selective depletion (medulla). Transient expression of N-type calcium channels may influence specific neurodevelopmental processes.
引用
收藏
页码：131 / 136
页数：6
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