ANOMALOUS RESPONSES TO HISTAMINE STIMULATION OF GUINEA-PIG ESOPHAGEAL MUSCULARIS MUCOSAE

被引：0
|
作者：
BAROCELLI, E
CHIAVARINI, M
MORINI, G
BALLABENI, V
VITALI, T
SILVA, C
IMPICCIATORE, M
机构：
[1] UNIV PARMA,INST PHARMACOL & PHARMACOGNOSY,VIA MASSIMO DAZEGLIO 85,I-43100 PARMA,ITALY
[2] UNIV PARMA,INST PHARMACEUT CHEM,DEPT PHARM,I-43100 PARMA,ITALY
来源：
AGENTS AND ACTIONS | 1991年 / 33卷 / 1-2期
关键词：
D O I：
10.1007/BF01993159
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The incomplete tachyphylaxis of the contractile response to the H-1-stimulants observed on guinea-pig oesophageal muscularis mucosae seems to be H-2- and H-3-antagonist as well as atropine- and tetrodotoxin-resistant. Lidocaine and eserine partially prevented this process probably by a mechanism independent of their main activity. The dualistic antagonism exerted by mepyramine and methysergide on reproducible histamine responses could be explained by a kinetic condition of "hemi-equilibrium state" together with changes of drug-receptor interaction and by non-specific properties of methysergide. On the whole, the present data indicate that the role of histamine in this tissue has still to be defined.
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页码：173 / 176
页数：4
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