Rosiglitazone: Effect on spontaneous and clomiphene citrate induced ovulation in Polycystic Ovary Syndrome

Objectives : To observe the effect of rosiglitazone on spontaneous and clomiphene citrate induced ovulation in patients of polycystic ovary syndrome (PCOS). Methods: Thirty diagnosed patients of PCOS were divided into two groups. Group I received only rosiglitazone and patients in Group II were given both rosiglitazone and clomiphene citrate for a period of three months. Serum levels of leutinizing hormone (LH), follicle stimulating hormone (FSH), testosterone, prolactin, progesterone, fasting glucose, and lipids were estimated before and after treatment and compared using paired student 't' test. Ovulation and pregnancy rates were noted. Results : Ovulation rates of 40% (6/15) and 66.67% (10/15) and pregnancy rates of 26.67% (4/15) and 40% (6/15) were recorded in group I and II respectively. No significant effect on other parameters was observed except a decrease in LH levels after treatment (P<0.01). Conclusion : Rosiglitazone appears to be a promising adjunct in management of insulin resistance and anovulation associated with PCOS.