SERUM LEVELS OF VITAMIN-D METABOLITES IN ISOTRETINOIN-TREATED ACNE PATIENTS

被引：0

作者：

RODLAND, O ^{[1
]}

AKSNES, L ^{[1
]}

NILSEN, A ^{[1
]}

MORKEN, T ^{[1
]}

机构：

[1] UNIV BERGEN,HAUKELAND HOSP,DEPT PEDIAT,N-5016 BERGEN,NORWAY

来源：

ACTA DERMATO-VENEREOLOGICA | 1992年 / 72卷 / 03期

关键词：

1,25 DIHYDROXYVITAMIN-D; RETINOID; SKELETAL METABOLISM;

D O I：

暂无

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Serum levels of vitamin D metabolites were determined in 11 patients treated for cystic acne with a four-month course of isotretinoin (Roaccutane(C)). The levels were measured before treatment and after two months of medication. We found a significant fall in the level of 1,25-dihydroxyvitamin D (p < 0.01) and a significant increase in the molar ratio of 24, 25-dihydroxyvitamin D to 25-hydroxvitamin D (p < 0.05). No significant changes were found for the vitamin D metabolites 25-hydroxyvitamin D or 24,25-dihydroxy-vitamin D, for serum calcium, phosphorus, alkaline phosphatase or parathyroid hormone. Our data indicate early changes in the metabolism of vitamin D in patients on retinoid treatment.

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页码：217 / 219

页数：3

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