ANTIGENIC HETEROGENEITY IN HUMAN OVARIAN-CANCER

被引：14
|
作者：
WELCH, WR
NILOFF, JM
ANDERSON, D
BATTAILE, A
EMERY, S
KNAPP, RC
BAST, RC
机构：
[1] BRIGHAM & WOMENS HOSP,DEPT OBSTET & GYNECOL,BOSTON,MA 02115
[2] NEW ENGLAND DEACONESS HOSP,DEPT SURG,BOSTON,MA 02215
[3] HARVARD UNIV,SCH MED,DANA FARBER CANC INST,BOSTON,MA 02115
[4] HARVARD UNIV,SCH MED,BOSTON,MA 02115
[5] DUKE UNIV,MED CTR,DEPT MED,DURHAM,NC 27710
[6] DUKE UNIV,MED CTR,DEPT MICROBIOL,DURHAM,NC 27710
[7] DUKE UNIV,MED CTR,DEPT IMMUNOL,DURHAM,NC 27710
[8] DUKE UNIV,MED CTR,DUK COMPREHENS CANC CTR,DURHAM,NC 27710
来源：
GYNECOLOGIC ONCOLOGY | 1990年 / 38卷 / 01期
关键词：
D O I：
10.1016/0090-8258(90)90003-4
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Primary and metastatic tumor tissues from 21 patients with ovarian epithelial cancer were studied with a panel of 8 monoclonal antibodies. Primary tumors reacted with 1 to 7 antibodies (mean, 3.5). Heterogeneity was observed even within histologic subtypes. Comparison of metastases (including ascites) with their respective primaries revealed differences in antigen profile in each of 10 cases studied. In one patient variable antigen expression was observed in five ascites samples collected over a 12-month period. These observations of antigenic heterogeneity and modulation with respect to site and time suggest that single monoclonal antibody immunotherapy would not be appropriate for all patients or even for a single patient over time. © 1990.
引用
收藏
页码：12 / 16
页数：5
相关论文
共 50 条
  • [1] ANTIGENIC HETEROGENEITY IN HUMAN OVARIAN-CANCER
    NILOFF, J
    WELCH, W
    TAYLOR, S
    BATTAILE, A
    ANDERSON, D
    KNAPP, RC
    BAST, RC
    GYNECOLOGIC ONCOLOGY, 1986, 23 (02) : 246 - 247
  • [2] HETEROGENEITY OF GLUTATHIONE CONTENT IN HUMAN OVARIAN-CANCER
    LEE, FYF
    VESSEY, A
    ROFSTAD, E
    SIEMANN, DW
    SUTHERLAND, RM
    CANCER RESEARCH, 1989, 49 (19) : 5244 - 5248
  • [3] HEREDITARY OVARIAN-CANCER - HETEROGENEITY IN AGE AT ONSET
    LYNCH, HT
    WATSON, P
    LYNCH, JF
    CONWAY, TA
    FILI, M
    CANCER, 1993, 71 (02) : 573 - 581
  • [4] TUMOR HETEROGENEITY AND HISTOPATHOLOGY IN EPITHELIAL OVARIAN-CANCER
    HERNANDEZ, E
    ROSENSHEIN, NB
    BHAGAVAN, BS
    PARMLEY, TH
    OBSTETRICS AND GYNECOLOGY, 1984, 63 (03): : 330 - 334
  • [5] HEREDITARY OVARIAN-CANCER - HETEROGENEITY IN AGE AT DIAGNOSIS
    LYNCH, HT
    WATSON, P
    BEWTRA, C
    CONWAY, TA
    HIPPEE, CR
    KAUR, P
    LYNCH, JF
    PONDER, BAJ
    CANCER, 1991, 67 (05) : 1460 - 1466
  • [6] ALLELOTYPE OF HUMAN OVARIAN-CANCER
    SATO, T
    SAITO, H
    MORITA, R
    KOI, S
    LEE, JH
    NAKAMURA, Y
    CANCER RESEARCH, 1991, 51 (19) : 5118 - 5122
  • [7] DEMONSTRATION OF SOMATIC REARRANGEMENTS AND GENOMIC HETEROGENEITY IN HUMAN OVARIAN-CANCER BY DNA FINGERPRINTING
    BOLTZ, EM
    HARNETT, P
    LEARY, J
    HOUGHTON, R
    KEFFORD, RF
    FRIEDLANDER, ML
    BRITISH JOURNAL OF CANCER, 1990, 62 (01) : 23 - 27
  • [8] OVARIAN SURFACE EPITHELIUM AND HUMAN OVARIAN-CANCER
    DIETL, J
    MARZUSCH, K
    GYNECOLOGIC AND OBSTETRIC INVESTIGATION, 1993, 35 (03) : 129 - 135
  • [9] HETEROGENEITY OF ANTIGEN EXPRESSION IN ADVANCED EPITHELIAL OVARIAN-CANCER
    BERCHUCK, A
    OLT, GJ
    SOISSON, AP
    KAMEL, A
    SOPER, JT
    BOYER, CM
    CLARKEPEARSON, DL
    LESLIE, DS
    BAST, RC
    AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1990, 162 (04) : 883 - 888
  • [10] HUMAN EPITHELIAL OVARIAN-CANCER ALLELOTYPE
    CLIBY, W
    RITLAND, S
    HARTMANN, L
    DODSON, M
    HALLING, KC
    KEENEY, G
    PODRATZ, KC
    JENKINS, RB
    CANCER RESEARCH, 1993, 53 (10) : 2393 - 2398
12345