REGIONAL VARIABILITY OF COLONOCYTE GROWTH AND DIFFERENTIATION IN THE RAT

被引：44
|
作者：
SATO, M
AHNEN, DJ
机构：
[1] DEPT VET AFFAIRS MED CTR 111E, 1055 CLERMONT, DENVER, CO 80220 USA
[2] ST MARIANNA MED UNIV, SCH MED, DEPT SURG, KAWASAKI 213, JAPAN
[3] UNIV COLORADO, SCH MED, DIV GASTROENTEROL, DENVER, CO 80202 USA
来源：
ANATOMICAL RECORD | 1992年 / 233卷 / 03期
关键词：
D O I：
10.1002/ar.1092330308
中图分类号：
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号：
100101 ;
摘要：
The location of stem cells and the direction of colonocyte migration in the normal rat colonic crypt were investigated using a serial bromodeoxyuridine (BrdU) and [H-3]thymidine labeling protocol. The results demonstrate that in the distal colon the stem cells are located in the crypt base and that cells migrate up toward the luminal surface. In the proximal colon, however, the stem cells are located in the midcrypt, and the colonocytes migrate in two directions, up toward the luminal surface and down toward the crypt base.
引用
收藏
页码：409 / 414
页数：6
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