A New ability for X-ray Medical Imaging Based on Gold Nanoparticles.

X-ray medical imaging is one of the most important imaging techniques because it is low-cost and reachable technique. But it has the weak ability of depict soft tissues and small details between soft tissues at the borders of interference. This limitation was overcome by using iodine-based contrast, however this X-ray contrast agent has many restrictions of utility because of its effects on the human body (side effects). One decade ago, a new variant X-ray contrast agent was found out and understudy to date. The new variance factor is the Nanomaterials and for special the gold, which overcome the restrictions because of the excellent properties of gold nano particles, where the biological apportionment of these particles is higher than iodine compounds. The interaction between bones and soft tissue is more apparent, stay longer at the targeted site which allows for a longer imaging time and all of the above factors enhance the X-ray diagnostic ability. The present study consists of three steps. The first step includes the synthesis of gold nanoparticles using a chemical method (reduction-mediated approach). The second step includes the selection of animal type, housing, preparing the tumor (Adenocarcinoma) and the tumor implantation. The third step consists of the intravenous administration of gold nanoparticles to infected mice then X-ray imaging was taken by conventional X-ray unit. The resulted X-ray images demonstrated that gold nanoparticles were attractive to move toward tumor site through the general circulation and spent more time at the tumor site (inverse the iodine contrast agent) which allows for a longer time of imaging, lower levels of toxicity and side effects. After that the X-ray images shows a lucid tumor appearance and measurable. All of above translated in X-ray diagnostic enhancement.