EFFECT OF MOTILIN ON THE L-LEUCINE TRANSPORT IN RABBIT JEJUNUM

被引：4
|
作者：
MARCO, R
NAVARRO, H
RODRIGUEZYOLDI, MJ
SORRIBAS, V
ALCALDE, AI
机构：
[1] UNIV ZARAGOZA,FAC VET,DEPT FISIOL,E-50013 ZARAGOZA,SPAIN
[2] UNIV ZARAGOZA,FAC VET,DEPT TOXICOL,E-50013 ZARAGOZA,SPAIN
来源：
PEPTIDES | 1995年 / 16卷 / 08期
关键词：
MOTILIN; L-LEUCINE TRANSPORT; RABBIT JEJUNUM; PKC;
D O I：
10.1016/0196-9781(95)02043-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Motilin is a gastrointestinal peptide that stimulates the gastrointestinal motility in several species. The aim of the present work has been to determine the effect of motilin on the L-leucine absorption in rabbit jejunum. The results show that motilin inhibits the L-leucine Na+-dependent system of transport located in the mucosal border mainly by diminishing the apparent V-max. Motilin did not directly affect the Na+-dependent system of transport, but it seems to act across the protein kinase C (PKC). These results suggest that motilin may act as a regulatory hormone of the intestinal absorption of nutrients.
引用
收藏
页码：1505 / 1510
页数：6
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