NICOTINAMIDE AND 3-AMINOBENZAMIDE INHIBIT RECOMBINANT HUMAN INTERFERON-GAMMA-INDUCED HLA-DR ANTIGEN EXPRESSION, BUT NOT HLA-A, HLA-B, HLA-C ANTIGEN EXPRESSION, ON CULTURED HUMAN THYROID-CELLS

被引:24
|
作者
HIROMATSU, Y
SATO, M
YAMADA, K
NONAKA, K
机构
[1] Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine, Fukuoka
关键词
D O I
10.1111/j.1365-2265.1992.tb02907.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVE We wished to investigate the effects of nicotinamide and 3-aminobenzamide, well known as inhibitors of poly(ADP ribose) synthetase, on interferon-gamma-induced HLA-DR antigen expression using cultured human thyroid cells from patients with Graves' disease. DESIGN AND MEASUREMENTS Cultured thyroid cells were incubated for 3 days with 10-400 U/ml of interferon-gamma in the presence of nicotinamide, 3-aminobenzamide, superoxide dismutase or catalase. The surface expression of HLA-DR and HLA-A, B, C antigen was measured by flow cytometry. RESULTS Nicotinamide and 3-aminobenzamide dose-dependently inhibited the induction of HLA-DR antigen expression by interferon-gamma, but not HLA-A, B, C antigen expression on cultured thyroid cells. Neither catalase nor superoxide dismutase, which are free-radical scavengers, inhibited the expression of HLA antigens on thyroid cells. CONCLUSIONS Our data suggest that inhibitors of poly(ADP ribose) synthetase may have differential effects on interferon-gamma-induced HLA-DR and HLA-A, B, C antigen expression, and suppress the autoimmune reactions associated with autoimmune thyroid disorders via the reduction of HLA-DR antigen expression on thyroid cells. The mechanism of the suppression of HLA-DR antigen expression is unlikely to be due to the free radical scavenging.
引用
收藏
页码:91 / 95
页数:5
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