DISTINCTIVE GLYCOLIPID PATTERNS IN WILMS-TUMOR AND RENAL-CELL CARCINOMA

被引：26
|
作者：
SAKAKIBARA, N
GASA, S
KAMIO, K
MAKITA, A
NONOMURA, K
TOGASHI, M
KOYANAGI, T
HATAE, Y
TAKEDA, K
机构：
[1] HOKKAIDO UNIV,SCH MED,INST CANC,BIOCHEM LAB,KITA KU,KITA 15,NISHI 8,SAPPORO,HOKKAIDO 060,JAPAN
[2] HOKKAIDO UNIV,SCH MED,INST CANC,DEPT UROL,SAPPORO,HOKKAIDO 060,JAPAN
[3] SAPPORO NATL HOSP,PEDIAT SECT,SAPPORO,JAPAN
来源：
CANCER LETTERS | 1991年 / 57卷 / 03期
关键词：
GLYCOLIPIDS; SULFOTRANSFERASE; WILMS TUMOR; RENAL CELL CARCINOMA;
D O I：
10.1016/0304-3835(91)90155-B
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Glycolipid patterns were analysed chromatographically in Wilms' tumor and renal cell carcinoma tissues and compared with those of uninvolved tissue. Ganglioside GM3 was found to be increased in both cancer tissues, whereas sulfatides accumulated only in renal cell carcinoma, as reported earlier. Neolactotetraosylceramide was detected in both cancer tissues, but not in the uninvolved kidney tissues. In four cases of Wilms' tumors, only a low level of sulfotransferase towards galactosylceramide was found in one case, while no activity was detected in the three other cases. Present results show that the increased sulfatide(s) in the renal cell carcinoma and the deficiency of the sulfatides in Wilms' tumors appear to be biochemical characteristics of histologically different carcinomas.
引用
收藏
页码：187 / 192
页数：6
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