EFFECTS OF TACRINE UPON MURINE NEUROBLASTOMA-CELLS

被引：5
|
作者：
ZATTA, P
ZAMBENEDETTI, P
MARTURANO, MB
PALUMBO, M
NICOLINI, M
机构：
[1] UNIV PADUA, DIPARTIMENTO BIOL, I-35131 PADUA, ITALY
[2] UNIV PADUA, DIPARTIMENTO SCI FARMACEUT, I-35131 PADUA, ITALY
来源：
JOURNAL OF NEURAL TRANSMISSION-GENERAL SECTION | 1995年 / 102卷 / 02期
关键词：
TACRINE; NEUROBLASTOMA; ALZHEIMERS DISEASE;
D O I：
10.1007/BF01276507
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Tacrine [9-amino-1,2,3,4-tetrahydroacridine] (THA), a potent acetylcholinesterasic inhibitor, is utilized in the pharmacological treatment of Alzheimer's disease (Birne and Arie, 1994). Cytopharmacology of THA is still largely to be discovered. In the present paper we report some effects produced by THA on murine neuroblastoma cells (N2A) used as an experimental model. N2A cells treated with THA at low concentration (1 mu M) showed a reduced cell's mitosis and a remarkable reduction of protein synthesis. Eventually, a marked reduction on the phosphorylation of proteins associated to neurofilaments 200 kD, is observed using specific antibody.
引用
收藏
页码：113 / 123
页数：11
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