ISLET-GRAFT DESTRUCTION BY A CD4+ T-CELL CLONE IS NOT CD8 T-CELL DEPENDENT

被引：0
|
作者：
HASKINS, K
BRADLEY, BJ
LAFFERTY, KJ
机构：
来源：
DIABETES NUTRITION & METABOLISM | 1992年 / 5卷 / 03期
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R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A CD4+ islet-specific clone, BDC-6.9, has been shown to initiate islet graft destruction in (CBA x NOD)F1 mice in which diabetes was induced by treatment with streptozotocin and then reversed by transplantation of NOD islets under the kidney capsule. In this study, we have shown that the BDC-6.9 clone can reinitiate the disease process in the absence of CD8 T-cells.
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页码：111 / 112
页数：2
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